Chelyabinsk State University (Senior Lecturer)
FSBEI HE ChelSU
UDK 57.08 Биологическая техника, экспериментальные методы и оборудование
In the experimental department of the Urals research center for radiation medicine (Chelyabinsk, Russia) the radiobiological studies are carried out with the IGUR-1M gamma installation. In this study, the numerical experiment has been performed to specify the radiation doses in experimental mice and corresponding uncertainties. We evaluate the factors converting the dose in air measured by the ionization chamber to the dose to an organism, which is dependent on the height of the cage with the animals. The relative standard uncertainties of radiation doses for mice under 7 days of age do not exceed 7%. For more active older animals, the uncertainty of the delivered radiation doses can reach 10%.
IGUR-1M, radiation dose, dose uncertainty, numerical experiment
1. Tryapicyna G.A., Tarasova S.P., Duhovnaya N.I., Osipov D.I., Pryahin E.A. Eksperimental'naya ocenka sochetannogo deystviya nitratov i ostrogo g-oblucheniya na rost zelenyh vodorosley Scenedesmus quadricauda//Radiacionnaya biologiya. Radioekologiya. 2012. № 3(52). S. 298-304.
2. Ahmadullina Yu.R., Styazhkina E.V., Gaynetdinova Yu.V., Petrova A.V. Mutagennoe deystvie ioniziruyuschego i neioniziruyuschego elektromagnitnogo izlucheniya na Drosophila melanogaster//Byulleten' eksperimental'noy biologii i mediciny. 2022. № 11(174). S. 633-636.
3. Aldibekova A.E., Styazhkina E.V., Pryahin E.A. Izuchenie kombinirovannogo deystviya impul'snogo magnitnogo polya i gamma-izlucheniya na chastotu hromosomnyh aberraciy v kletkah kornya Allium cepa L.//VIII S'ezd po radiacionnym issledovaniyam. Tezisy dokladov (Moskva, 12–15 oktyabrya, 2021). Dubna: Izd-vo Ob'edinennyy institut yadernyh issledovaniy, 2021. S. 51.
4. Kogarko I.N., Petushkova V.V., Kogarko B.S., Pryahin E.A., Neyfah E.A., Ktitorova O.V., Andreev S.S., Ganeev I.I., Kuz'mina N.S., Selivanova E.I., Pelevina I.I. Issledovanie deystviya ioniziruyuschego izlucheniya na radiacionno-induciruemye izmeneniya kletok sistemy krovi myshey na urovne organizma//Radiaciya i risk. 2023. № 1(32). S. 48-60.
5. Atamanyuk N.I., Styazhkina E.V., Obvinceva N.A., Tryapicyna G.A., Shaposhnikova I.A., Andreev S.S., Aldibekova A.E., Peretykin A.A., Pryahin E.A. Kinetika gibeli i vosstanovleniya kletok kostnogo mozga u myshey dvuh liniy s raznoy radiochuvstvitel'nost'yu posle ostrogo g-oblucheniya// Voprosy radiacionnoy bezopasnosti. 2021. № 4. S. 62-72.
6. Akleev A.V., Pryahin E.A., Tryapicyna G.A, Ostroumov Yu.I., Semenkova L.N., Dudich I.V., Grebennikov E.P., Shmelin P.S. Pat. Ru 2699040 C1 MPK A61K 38/18 (2006.01); A61P 39/00(2006.01) Sposob ekstrennoy profilaktiki i lecheniya ostroy luchevoy bolezni. Zayavl. 23.07.2018. Opubl. 03.09.2019. Byul. № 25. S. 43. Ispol'zuya popravku r k pokazaniyam ionizacionnoy kamery, my isklyuchaem sistematicheskuyu komponentu obschey neopredelennosti ocenki doz. V takom sluchae neopredelennost' koefficienta r budet sootvetstvovat' neopredelennosti dozy oblucheniya zhivotnogo.
7. Akleev A.V., Shaposhnikova I.A., Churilova I.V., Grebenyuk A.N., Pryahin E.A. Vliyanie preparata superoksiddismutazy «Reksod» na chislo KOEs u obluchennyh myshey//Radiacionnaya biologiya. Radioekologiya. 2021. № 2(61). S. 159-167.
8. Atamanyuk N.I., Pryahin E.A., Styazhkina E.V., Obvinceva N.A., Tryapicyna G.A., Peretykin A.A., Andreev S.S., Aldibekova A.E., Akleev A.V. Ocenka personificirovannoy reakcii gemopoeticheskih stvolovyh kletok na gamma-obluchenie s ispol'zovaniem gumanizirovannyh myshey//Medicina ekstremal'nyh situaciy. 2023. № 1. S. 44-50.
9. Atamanyuk N.I., Andreev S.S., Peretykin A.A., Styazhkina E.V., Obvinceva N.A., Tryapicyna G.A., Pryahin E.A. Gumanizirovannye myshi kak model' dlya ocenki reakcii gemopoeticheskih stvolovyh kletok cheloveka na radiacionnoe vozdeystvie//Byulleten' eksperimental'noy biologii i mediciny. 2023. № 7(176). S. 44-48.
10. Y. Choi, Y.J. Jang, K.B. Kim, J. Bahng, S.H. Choi, «Characterization of Tissue Equivalent Materials Using 3D Printing for Patient-Specific DQA in Radiation Therapy», Appl. Sci., no. 12, pp. 9768., 2022.
11. Shishkina E.A., Sharagin P.A., Tolstyh E.I. Neopredelennost' ocenki doz v kostnom mozge ot 89,90Sr iz-za izmenchivosti himicheskogo sostava i plotnosti kosti//Radiacionnaya gigiena. 2023. № 16(2). S. 32-43.
